Benzodiazepines as Centrally Acting Skeletal Muscle Relaxants



Gatmedicele.orgSkeletal muscle relaxants classification


03/25/2015
02:40 | Author: Madison Brown

Skeletal muscle relaxants otc
Benzodiazepines as Centrally Acting Skeletal Muscle Relaxants

in Pharmacology.

Mechanism of Action of centrally acting drugs.

This is achieved either by increasing the release of inhibitory neurotransmitters or decreasing the release of excitatory neurotransmitters. The pain encountered in these spasms is due to release of subs P, which is decreased by these drugs.

These drugs depress the pulse transmission in polysynaptic pathways.

Dantrolene -Directly Acting Skeletal Muscle Relaxant February 18, 2013 August 17, 2012 August 17, 2012.

They can be given orally or parentally. They can be given I/V for controlling the convulsions in status epilepticus, as well as in tetanus. They are metabolized by the liver.

Suxamethonium -Depolarizing Neuromuscular Blocker.

Mainly affect CNS, evident in the form of sedation, drowsiness, ataxia, impaired judgment. Only in increased doses can cause depression of CVS and respiratory system.

Baclofen and Progabide -GABA Analogues.

1. hyperactive stretch reflexes or.

Spasm may be due to:

Mephenesin and Meprobamate -Propandiol Derivatives.

These drugs do not improve the power or functions of muscles; rather actually decrease the power of muscles.

Tubocurarine -Non-depolarizing Neuromuscular Blocker.

Factors affecting actions of Neuromuscular blockers.

Given in a dose of 5 mg, which may be increased to 60 mg.

In patients of stroke, spasticity is important because it helps in walking, providing support. When skeletal muscle relaxants are given, they expose the weakness of limbs.

Decrease the hyperactivity of stretch reflex arc, as well as decrease the activation of alpha motor neurons.

Clonazepam and Nitrazepam have similar actions to that of diazepam, but have shorter duration of action. Skeletal Muscle Relaxants.

Atracurium, Cisatracurium, Gallamine and Steroid Derivatives -Non Depolarizing Neuromuscular Blockers.

They are used to decrease the spasm and release spasticity as well as to reduce the pain.

2. increased activation of alpha motor neurons or.

Cyclobenzaprine, Orphenadrine and Tizanidine.

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3. imbalance between excitatory and inhibitory neurotransmitters.

They produce effects centrally in brain or spinal cord.

They produce their effects by GABAergic effect meaning that they potentiate the effects of GABA, without directly activating GABA receptors. They bind GABA A component of supramolecular complex.


Skeletal muscle relaxants classification